吸毒人群丙型肝炎病毒感染危险因素的研究

A Study on the Risk Factors for Hepatitis C Virus Infection among Drug Users

摘要: 采用病例对照的研究方法，对广州市531名吸毒人员进行丙型肝炎病毒（HCV）感染危险因素的调查，资料采用Logistic回归方法分析。结果表明：静脉吸毒（OR=6.68，P<0.001），非固定婚外性伴侣（OR=3.71，P<0.001），输液史（OR= 2.64，P< 0.01）和抗-HBc阳性（OR= 1.74，P< 0.05）是HCV感染独立的危险因素，而在性生活中使用避孕套（OR= 0.37，P< 0.005）是保护因素。提示广州市吸毒人群HCV感染的主要途径是血液传播，同时性传播途径也起着重要的作用。

Abstract: To investigate the possible risk factors for hepatitis C virus infection, a case-control study category matching was conducted among 531 drug users. In unconditional Lolgistic regression, indepentent risk factors associated with anti-HCV included history of intraveno us drug use(IVDU)(odds ratioOR= 6.68, P<(0.001), multiple sexual partners(OR=3.71, P< 0.001), transfusion(OR= 2.64, P< 0.0001) and anti-HB cpositivity(OR= 1.71, P< 0.05), whereas condomuse in sexual activity was protective factor(OR= 0.37, P< 0.005). Results suggest that IVDU and transfu sionare the primary route of transmission and sexual transmission may also play an important role in transmission of HCV among drug users.