16种中药的抗4NQO致突变作用

Antimutagenicity of 16 kinds Chinese Herbal Drugs to 4NQO Induced Mutagenisis

摘要: 用E.coli CM891 菌株的正向突变（SM^r-5）和回复突变（TrP⁺）双重指标，以细胞内抗突变作用的模式检测了16 种中药水提取物的抗4NQO 的致突变活性。结果显示：诃子、首乌、女贞子和带蒂菱壳具有拮抗4NQO 诱发的正向突变和回复突变的作用；带蒂菱壳还具有抗自发正向和回复突变的作用。白芍具有促进4NQO 的致突变活性。

Abstract: Antimutagenicity effects of 16 Kinds Chinese Herbal Drugs on a dual biological indicators-fo rward (SM^r-5) and reversion (Trp⁺)mutations induced by 4-nitroquinoline-1-o xide (4NQO) were determined by a bioantimutagenic model in Escherichia coli strain CM891, respectely.Results showed the water extract of Fructus chebulae, Radix polygoni multiflori, Fructurs lig ustri lucidi and shell of water chestnut with a pedicle could produce antimutagenisis against 4NQU-induced fo rward and reversion mutation.Futher, shell of w ater chestnut with a pedicle also could do antimutag enisis to spo ntaneous ones.However, Paeonia lactiflora could prolmote 4NQO-induced mutation.