Abstract: The tox icity and ant-i tumor activity of Momor dica charatia L. were studied. T he r esults showed the acute LD50 value of Momordica charatia L. jiuce in gastr ic( ig) was??20mg/ kg and LD50=296??3mg/ kg injected intr aper itoneally. The juice of Momor dica charatia L. didn't show any inhibitor y action to S- 180 byig, but the ratio of inhibit ion w as 39. 3% by ip. On the contrar y, the extract of Momordica char at ia L. residue w hich were extr acted by a-lcohol didn't show inhibitory action to S- 180 by ip, but did byig, and the ratio of inhibition was up to 37. 1%.