Abstract: To implement the national Center for Disease Control and Prevention’s mandate for the development of provincially coordinated regional infectious disease emergency command and operation platforms and to enhance the efficiency and command capabilities of infectious disease emergency response. Based on the requirements of the national plan, combined with an analysis of the current status and shortcomings of emergency management informatization in Zhejiang province, this article proposes a design framework and implementation path for a provincially coordinated regional emergency command and operation platform. The overall system architecture is designed around the emergency command operation process, incorporating technologies such as artificial intelligence language models, WebGIS, multimedia converged communication, and situational awareness models to construct a digital and intelligent emergency command and operation platform. The platform encompasses seven key subsystems: emergency duty management, intelligent epidemiological investigation, cross-regional collaborative investigation, visualized display, auxiliary decision-making, comprehensive management of emergency command and dispatch, and comprehensive management of health emergency resource support. It preliminarily achieves unified command, efficient collaboration, scientific decision-making, and closed-loop information management throughout the entire emergency response process. This research contributes to promoting the digital and intelligent development of infectious disease emergency command and management, providing a valuable reference model for the construction of provincially coordinated platforms in various regions.